منابع مشابه
Cardiac Proteomics
Approximately one-third of all deaths are attributed to cardiovascular diseases, and ischaemic heart disease is the primary cause of death globally. Hence there continues to be a pressing need for advances in preventative, diagnostic, and interventional strategies for cardiovascular disease. The mul-tifactorial nature of cardiovascular disease, which encompasses both genetic and environmental f...
متن کاملCardiac myocyte exosomes: stability, HSP60, and proteomics.
Exosomes, which are 50- to 100-nm-diameter lipid vesicles, have been implicated in intercellular communication, including transmitting malignancy, and as a way for viral particles to evade detection while spreading to new cells. Previously, we demonstrated that adult cardiac myocytes release heat shock protein (HSP)60 in exosomes. Extracellular HSP60, when not in exosomes, causes cardiac myocyt...
متن کاملProteomics and microRNA profiling in cardiac fibrosis
Cardiac fibrosis is characterized by the deposition of extracellular matrix (ECM) and mediated by cardiac fibroblasts via the renin-angiotensin system (RAS) and transforming growth factor beta (TGFβ) signaling pathways. Recognition of TGFβ by fibroblasts leads to myofibroblast differentiation as well as induction of ECM protein expression. An imbalance between proand anti-fibrotic signals resul...
متن کاملPharmaceutical Advances and Proteomics Researches
Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...
متن کاملEditorial Extracellular Matrix Proteomics in Cardiac Ischemia / Reperfusion
Prolonged myocardial ischemia leads to myocyte necrosis, which initiates a localized inflammatory response that catabolizes the cellular debris and initiates deposition of extracellular matrix (ECM) proteins.1 In addition to providing a vital structural framework for the three-dimensional organization of cells, the ECM determines the physical properties of biological tissues and acts as a dynam...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2014
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2014/903538